Main Estrogen of Humans β-estradiol For Neuroprotective and Regulates Bone Maintenance

Main Estrogen of Humans β-estradiol For Neuroprotective and Regulates Bone Maintenance

What is Estradiol?

Estradiol (17β-estradiol) is a sex hormone. It represents the main estrogen of humans. Estradiol not only has an important effect on reproduction and sexual function, but also affects other organs, including bone structure.

In the reproductive years, most of the female estradiol is produced by the ovaries, and a small amount of estradiol is also produced by the adrenal cortex. In men, the testes produce estradiol.

In plasma, estradiol binds primarily to sex hormone binding globulin (SHBG) and also to albumin, with only a portion having free and biological activity.

Female serum estradiol measurements primarily reflect ovarian activity. During pregnancy, estrogen levels, including estradiol, steadily rise to full term. Estradiol increases due to placenta production.

In adult premenopausal women, estrogen ovarian production is stimulated by luteinizing hormone (LH) and follicle stimulating hormone (FSH) during the menstrual cycle. In adult women, estradiol levels are measured in fertility and menstrual irregularities, and ovarian follicular function is monitored during induction of ovulation. In females, estradiol acts as a growth hormone for reproductive organ tissues. The development of female secondary sexual characteristics is driven by estradiol. Estradiol is also involved in male fertility. Estradiol regulates bone maintenance. Postmenopausal women experience accelerated bone loss due to relative estrogen deficiency.

Estradiol affects the production of a variety of proteins, including lipoproteins, binding proteins, and proteins responsible for blood coagulation. Estrogen has been found to have neuroprotective functions.

The activity of estradiol involves certain types of cancer, such as breast cancer and endometrial cancer. In addition, there are some good gynecological diseases that depend on estrogens such as endometriosis, uterine leiomyoma and uterine bleeding.

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