Active Pharmaceutical Ingredients Formestane CAS 566-48-3 for Advanced Breast Cancer

Active Pharmaceutical Ingredients Formestane CAS 566-48-3 for Advanced Breast Cancer
 

A. Formestane is a synthetic steroidal substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.

B. Formestane is a drug that has been previously used in breast cancer treatment. Like most drugs which have some sort of phsyique usage, athletes eventually get a hold of it. Formestane is currently one of the best legal anti-estrogens out there. It is classified as an irreversible arromatase inhibitor, meaning, it destroys the aromatase enzyme.

C. Formestane is often used to suppress estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor.
Formestane has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified.

Application:

Formestane has a very long active life on the order of 24-36 hours.This amount will usually last you about 3-4 weeks at a sufficient dosage of 200-400mg per day.I have found 200mg a day to be perfect for on cycle anti-estrogen usage and for post-cycle recovery of natural testosterone.Formestane has zero negative feedback (even though it is an androgen by definition) and serves to elevate natural testosterone as well as any anti-estrogen/anti-aromatase drug out there, next to clomid.

Formestane attacks the aromatase enzyme and is therefore a first line inhibitor.So if you need immediate relief of estrogen during your cycle, you need a second class drug (estrogen receptor blocker) such as nolvadex or clomid.Formestane is a lot like arimidex in its mechanism of action in attacking the aromatase enzyme itself.

Formestane decreases SHBG by 34% thus increasing androgen activity, which basically makes androgens/steroids in your systems MORE effective WITHOUT any increase in dosage.

Formestane increases IGF-1 levels by a whopping 26%.Doing so creates the perfect anabolic muscle building environment on cycle, off cycle and during pct.

Formestanes Recommended Dosage:

Formestanes was dosed at 100-200mgs per application. Users would apply it onto clean, dry skin and rub in thoroughly; usually on the thighs or upper arms. It took 1 to 5 minutes to dry.

Dosages:

Lentaron is available as an intramuscular depot injection, and is often found in 2 ml ampules of 125 mg/ml solution. The recommended dosage for bodybuilder purposes is the same as that for advanced breast cancer therapy, namely 250 mg per week. Formestane can also be found, and taken in the same 250 mg per week dosage in its oral form, but the oral had poor bioavailability is no longer a popular version of this drug.