Orally Active Prohormone 1,4-Androstadienedione Powder For Bodybuilding CAS 897-06-3

Orally Active Prohormone 1,4-Androstadienedione Powder For Bodybuilding CAS 897-06-3

Androstadienedione (1,4-androstadiene-3,17-dione) is a next generation orally active prohormone. It is a direct precursor to the anabolic steroid boldenone. Boldenone is an anabolic steroid most often found in injectable form as a veterinary medication (boldenone undecylenate). It is chemically a derivative of testosterone. 1,4-androstadiene-3,17-dione converts to estrogen at roughly half the rate of androstenedione and testosterone. This significantly reduces the level of estrogen buildup during use compared to that achieved with testosterone precursors, and similarly also lowers the chance of noticing strong estrogen related side effects such as increased body fat, gynecomastia and definition hiding water retention. Androstadienedione is used as a pharmaceutical intermediate for further synthesis of female sex hormones, hormone replacement therapies and oral contraceptives.

Description:

Androstadienedione is used for simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroid, norethisterone, testosterone propionate in the middle body, is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.

Androstadienedione is the precursor to bolde-none, and as of January 4, 2010 is a Schedule III Controlled Substance. In 2004 the United States Congress passed the Anabolic Steroid Control Act of 2005 which placed 36 steroids and over the counter pro-hormones into schedule III of the Controlled Substances Act.

Application:

4-Androstenedione is the common precursor of male and female sex hormones. Some 4-Androstenedione is also secreted into the plasma, and may be converted in peripheral tissues to testosterone and estrogens.

4-Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of 17-hydroxypregnenolone to dehydroepiandrosterone by way of 17,20-lyase, with subsequent conversion of dehydroepiandrosterone to 4-Androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to 4-androstenedione directly by way of 17,20-lyase. Thus, 17,20-lyase is required for the synthesis of 4-androstenedione, whether immediately or one step removed.

The production of adrenal 4-Androstenedione is governed by ACTH, whereas production of gonadal 4-Androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total 4-androstenedione(about 3 mg/day). After menopause, 4-androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. Nevertheless, 4-androstenedione is the principal steroid produced by the postmenopausal ovary.

In this legislation Androstadienedione was classified as a controlled substance and bol-dione remained legal. In April 2008 the United States Drug Enforcement Administration published an "Initial Notice of Proposed Rulemaking" concerning the scheduling of three anabolic substances: bol-dione, desoxymethyltestos-terone, and diene-dione.

In 2008, at the time of the proposal, these three substances were listed as ingredients in more than 58 dietary supplements which were available for purchase over the counter.
 

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