|Place of Origin:||China|
|Minimum Order Quantity:||10g|
|Packaging Details:||Foil bag and Disguised bag|
|Delivery Time:||3-5 work days|
|Payment Terms:||Western Union, T/T, MoneyGram, Bitcoin|
Pharmaceutical material Mepivacaine HCL For Local Infiltration and Regional Anesthesia
1. Mepivicaine hydrochloride is a local anesthetic of the amide type. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal.
2. Half life of Mepivacaine hydrochloride, the half-life of mepivacaine in adults is 1.9 to 3.2 hours and in neonates to 8.7
Mepivacaine HCL Usage/Application:
Mepivacaine is a local anesthetic of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine) and is marketed under various trade names including Carbocaine and Polocaine.
Mepivacaine is used in any infiltration and regional anesthesia.
It is supplied as the hydrochloride salt of the racemate.
|Product name||Mepivacaine HCL|
|Melting point||288-290 °C (dec.)(lit.)|
Mepivacaine stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthesia.
Mepivacaine is rapidly metabolized, with only a small percentage of the anesthetic (5 to 10 percent) being excreted unchanged in the urine. Mepivacaine because of its amide structure, is not detoxified by the circulating plasma esterases. The liver is the principal site of metabolism, with over 50 percent of the administered dose being excreted into the bile as metabolites. Most of the metabolized Mepivacaine is probably resorbed in the intestine and then excreted into the urine since only a small percentage is found in the feces. The principal route of excretion is via the kidney. Most of the anesthetic and its metabolites are eliminated within 30 hours. It has been shown that hydroxylation and N-demethylation, which are detoxification reactions, play important roles in the metabolism of the anesthetic. Three metabolites of Mepivacaine have been identified from adult humans: two phenols, which are excreted almost exclusively as their glucuronide conjugates, and the N-demethylated compound (2', 6' - pipecoloxylidide).
The onset of action is rapid (30 to 120 seconds in the upper jaw; 1 to 4 minutes in the lower jaw) and Mepivacaine HCl 3% will ordinarily provide operating anesthesia of 20 minutes in the upper jaw and 40 minutes in the lower jaw .
Mepivacaine HCl 2% with Levonordefrin 1:20,000 provides anesthesia of longer duration for more prolonged procedures, 1 hour to 2.5 hours in the upper jaw and 2.5 hours to 5.5 hours in the lower jaw.
Mepivacaine does not ordinarily produce irritation or tissue damage.
Levonordefrin is a sympathomimetic amine used as a vasoconstrictor in local anesthetic solutions. It has pharmacologic activity similar to that of Epinephrine but it is more stable than Epinephrine. In equal concentrations, Levonordefrin is less potent than Epinephrine in raising blood pressure, and as a vasoconstrictor.
INDICATIONS AND USAGE:
Mepivacaine is indicated for production of local anesthesia for dental procedures by infiltration or nerve block in adults and pediatric patients.
Mepivacaine is contraindicated in patients with a known hypersensitivity to amide-type local anesthetics.
Q1: Have your Product Quality been Approved by Third Party Lab ?
A: Yes, All products are strictly tested by our QC , confirmed by QA and approved by third party lab in China , USA , Canada , Germany , UK , Italy , France etc. So you could be relieved to choose us.
Q2: Do you Accept Sample Order ?
A: Yes, we accept small order from 10g , 100g and 1kg for your evaluation quality of our goods.
Q3 :Can I get a sample ?
A: Of course. for most products we can provide you a free sample , while the shipping cost should undertake by you.
Q4: Do you accept VISA business credit card ?
A: Sorry we don't accept VISA credit card , we'd like to accept Western Union , Moneygram , T/T&Bitcoin.
Why Choose Us ?
1. Quality : we deal with steroid relevant products over 15 years, and have many stable customers from all over the world. All of them witness our products' quality.
2. Package : Different package for different customs results in high rate of customs clearance.
3. Delivery: No matter where you are from, safe delivery will be finished within 7 working days.
4. Guarantee: Reship policy will be shown to you before your order. The more you buy, the more discounts you will enjoy.
Contact Person: Miss. Gayle