|Place of Origin:||China|
|Minimum Order Quantity:||10g|
|Packaging Details:||Foil bag and Disguised bag|
|Delivery Time:||3-5 work days|
|Payment Terms:||T/T, Western Union, MoneyGram, Bitcoin|
Non-Hormonal 7-Keto-dehydroepiandrosterone For Increased Metabolism and Weight Loss
7-Keto DHEA (3-acetyl-7-oxo-dehydroepiandrosterone) is a non-hormonal, naturally occurring metabolite of DHEA.
|Product name||7-keto DHEA /7-Keto-dehydroepiandrosterone|
|Melting point||240.0-244.0 oC|
|Boiling Point||477.1 oC at 760 mmHg|
|Flash Point||256.5 oC|
7-Keto-DHEA (also known as 7-Keto, 7-ketodehydroepiandrosterone, or 7-oxodehydroepiandrosterone) is a steroid produced by metabolism of the prohormone It is often used as the acetate ester prodrug 7-Keto-DHEA acetate.
7-Keto is unique among other derivatives of DHEA because of its oxygenated 7-position. This molecular configuration imparts different characteristics to the molecule, and research reveals that 7-Keto DHEA has multiple distinct effects in the body.Such as, Increased metabolism/weight loss, Age-related immune enhancement.
7-Keto DHEA Benefits:
7-Keto DHEA has been shown to supplement resting metabolic rate, which can assist in promoting healthy body composition in combination with a proper diet and workout regimen.
One study found that the resting metabolic rate was increased by 1.4%. This is particularly helpful during dieting because the bodyâ€™s metabolic rate is inclined to go down since less food is being consumed.
7-Keto DHEA is a non-stimulant, which also makes it a good choice for supplementing resting metabolic rate as an alternative to caffeine. Since 7-Keto DHEA is a non-stimulant, the metabolic effects of caffeine can be had without the jitters.
Research suggests that 7-Keto DHEA may also increase thermogenic enzymes, promoting natural thermogenesis. Thermogenesis is the production of heat, especially as it relates to the human body. This process burns calories and can help to achieve desirable body composition
7-Keto DHEA vs. DHEA
7-Keto DHEA is a metabolite of its parent DHEA, meaning that it is a product of DHEA that has been metabolized. When the androgenic and estrogenic effects of DHEA are undesirable, 7-Keto DHEA can be used in its place.
7-Keto DHEA Dosage:
Recommended daily dosage is 200-400mg, split between two 100-200mg doses.
7-Keto-DHEA has a number of chemical names, including:
For the acetate ester:
7-Oxo-dehydroepiandrosterone acetate (7-oxo-DHEA acetate)
Note: "Keto" can be substituted for "oxo" in the above names.
7-Keto-DHEA has been the subject of a series of toxicological evaluations. These studies include: AMES Mutagenicity Test, Acute Oral Dose LD50 in Rats, Escalating Dose Oral Gavage in Rhesus Monkeys and 28 Day Oral Gavage in Rhesus Monkeys.
There were no adverse effects in any of these studies. This pre-clinical work was followed by a Phase I safety study in humans performed by Davidson and colleagues at the Chicago Center for Clinical Research. This study was published in Clinical Investigative Medicine and indicated that 7-keto-DHEA was safe for human consumption at doses up to 200 mg per day for 4 weeks. As in the toxicological studies, there were no serious adverse reactions or hormone related side effects reported. Data on the safety of long-term use (beyond 4 weeks) are lacking.
In addition, a complete pharmacokinetic analysis was completed as part of this study. This pharmacokinetic analysis describes exactly how the body absorbs, metabolizes, distributes and excretes 7-keto-DHEA. It reveals that 7-keto-DHEA is rapidly absorbed and converted to its sulfate derivative, it reaches peak plasma concentrations in 2.2 hours and has a half-life of 2.17 hours and there is no accumulation with repeated dosing.
To date, there have been two pre-market notifications filed with the FDA announcing intent to market 7-keto-DHEA as a dietary ingredient. These notifications had to demonstrate to FDA’s satisfaction that there is no issue with the safety of the subject ingredient. The FDA had no objection, in each of these notifications, to the marketing and sale of 7-keto-DHEA.
Effects and uses
7-Keto-DHEA is unique among other derivatives of DHEA because of its oxygenated 7-position. This molecular configuration imparts different characteristics to the molecule, and research reveals that 7-keto-DHEA has multiple distinct effects in the body.
Increased metabolism/weight loss
7-Keto-DHEA demonstrates documented thermogenic activity in rats. This is accomplished through the activation of three thermogenic enzymes: Glycerol-3-Phosphate Dehydrogenase, Malic Enzyme and Fatty Acyl CoA Oxidase. In keeping with the biological definition of thermogenesis, all three of these enzyme activations drive energy-producing substrates in a direction of less efficient ATP production relative to heat production. The enzymes also promote the utilization of fat stores for energy and heat production. This is the basis for the ability of 7-keto-DHEA to enhance thermogenesis and, through that mechanism, accelerate the utilization of fat stores for energy.
A 2007 study demonstrated that administration of 7-keto-DHEA to overweight adults in conjunction with a calorie-restricted diet effectively reverses the decline in resting metabolic rate (RMR) normally associated with dieting. 7-Keto-DHEA demonstrated an ability to increase RMR by 1.4% above baseline levels and demonstrated a 5.4% increase in daily RMR when administered with a calorie-restricted diet.
7-Keto-DHEA achieves this thermogenic effect without cardiovascular or central nervous system side effects, which are commonly seen with stimulant-associated thermogenic agents.
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