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Weight Loss Orlistat Powder For the Treatment of Obesity and Hyperlipidemia CAS 96829-58-2

Weight Loss Orlistat Powder For the Treatment of Obesity and Hyperlipidemia CAS 96829-58-2

    • Weight Loss Orlistat Powder For the Treatment of Obesity and Hyperlipidemia CAS 96829-58-2
    • Weight Loss Orlistat Powder For the Treatment of Obesity and Hyperlipidemia CAS 96829-58-2
    • Weight Loss Orlistat Powder For the Treatment of Obesity and Hyperlipidemia CAS 96829-58-2
    • Weight Loss Orlistat Powder For the Treatment of Obesity and Hyperlipidemia CAS 96829-58-2
  • Weight Loss Orlistat Powder For the Treatment of Obesity and Hyperlipidemia CAS 96829-58-2

    Product Details:

    Place of Origin: China
    Brand Name: RAWSGEAR
    Certification: ISO9001
    Model Number: 96829-58-2

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    Minimum Order Quantity: 10g
    Price: Negotiable
    Packaging Details: Foil bag and Disguised bag
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    Weight Loss Orlistat Powder For the Treatment of Obesity and Hyperlipidemia CAS 96829-58-2



    Quick details:


    Product name Orlistat
    CAS No. 96829-58-2
    MF C29H53NO5
    MW 495.73
    EINECS 639-755-1
    Melting point <50 °C





    Orlistat blocks some of the fat which you eat, keeping it from being absorbed because of your body. Orlistat is used to aid in weight reduction, or to lessen the risk of regaining weight lost.

    This medicine is employed together with a reduced-calorie diet. Orlistat is good for use only in grown-ups. Orlistat (prescription and nonprescription) is utilized with an individualized low-calorie, low-fat eating and working out program to help lose weight. Prescription orlistat is used in overweight people who can also have high blood pressure, diabetes, high-cholesterol, or coronary disease.

    Orlistat is also used after weight-loss to help keep from gaining back that weight. Orlistat is within a class of medications called lipase inhibitors. It functions by preventing a number of the fat in foods eaten from being absorbed from the intestines. This unabsorbed fat will be removed from our bodies in the stool.

    Orlistat is currently internationally recognized as a new type of weight loss lipid-lowering drugs with the marketed product being under the name of Xenical. It was first listed in New Zealand in 1998 with annual sale of $ 146 million at that time. In 2007, the sale reaches $ 538 million, Orlistat occupy 80% of the market share of the global weight-loss market with the annual sale of only China Hong Kong year reaching 80 million US dollars.


    Orlistat is a long-acting and potent specific inhibitor of gastrointestinal tract lipase, appearing as white or white-like powder at room temperature and being insoluble in water, soluble in chloroform and easily soluble in ethanol. It can form covalent bonds with the active serine sites of the gastric lipase and the pancreatic lipase in the stomach and small intestine cavity, resulting in inactivation of the enzymes. Fat in food can’t be broken down into free fatty acids and monoacylglycerols so that the fat can’t be absorbed and utilized, thereby having reduced the body's calorie intake to control the body weight.


    The drug does not need to be absorbed through the body. At normal doses, the absorption of fat can be inhibited by 30%. There is little absorption after oral administration. It can be subject to metabolic inactivation in the intestine with the metabolic sites located in the gastrointestinal wall. The elimination half-life is about 14 to 19 hours. About 97% of the goods are excreted with the feces, of which 83% are in the prototype.


    Clinically orlistat can be applied to the treatment of obesity and hyperlipidemia. Under normal circumstances, it can be subject to oral administration at a dose of 120 mg for three times per day. Take it during the meal or 1 hour after a meal. After 2 weeks of administration, the body weight can begin to decline. It can be taken continuously for 6 to 12 months. If the dose is increased to above 400 mg daily, the effect will no longer be further enhanced.

    Fat Loss Mechanism:

    Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. In the intestine, an enzyme called lipase (produced primarily by the pancreas) breaks apart fat in food so that it can be absorbed into the body. Orlistat blocks the action of lipase and thereby prevents the breakup and absorption of fat. Orlistat blocks absorption of about 25% of the fat in a meal. The unabsorbed fat is excreted in the stool.

    This medication is used along with a doctor-approved reduced-calorie diet, exercise, and behavior modification program to help significantly overweight (obese) persons lose weight. Taking orlistat can also help prevent you from regaining the weight you have lost. Losing weight and keeping it off can reduce the many health risks that obesity causes, including heart disease, diabetes, high blood pressure, some forms of cancer, certain breathing problems, and a shorter life span.

    Dietary fats need to be broken down into smaller pieces before the body can absorb them. Orlistat works by blocking the enzyme that breaks down fats in your diet. This undigested fat then passes out of your body in your bowel movement. Orlistat does not block the absorption of calories from sugar and other non-fat foods, so you still need to restrict your total intake of calories.


    Chemical properties of the Orlistat:

    Property Name Property Value
    Covalently-Bonded Unit Count 1
    Isotope Atom Count 0
    Undefined Bond Stereocenter Count 0
    Defined Bond Stereocenter Count 0
    Undefined Atom Stereocenter Count 0
    Defined Atom Stereocenter Count 4
    Heavy Atom Count 35
    Formal Charge 0
    Compound Is Canonicalized True
    XLogP3-AA 10
    Exact Mass 495.392 g/mol
    Monoisotopic Mass 495.392 g/mol
    Topological Polar Surface Area 81.7 A^2
    Complexity 579
    Rotatable Bond Count 23
    Hydrogen Bond Acceptor Count 5
    Hydrogen Bond Donor Count 1
    Molecular Weight 495.745 g/mol


    Uses of Orlistat:

    1) An antiobesity agent. A pancreatic lipase inhibitor. Antiobesity agent.

    2) antidiabetic

    3) Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.

    4) Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption. Tetrahydrolipstatin is widely used for the treatment of obesity.


    Dosage of Orlistat : 

    Orlistat comes in the form of turquoise, hard-gelatin capsules that contain pellets of powder and weighs 120-mg. The recommended daily dosage is three capsules a day. You shouldn’t take all three pills at a go, but instead take each tablet with the main meal that contains fat, i.e., one for breakfast, one for lunch, and one for supper. You can take each pill with a meal or up to one hour after a meal. In case a meal is often missed, or if your meal does not contain fat, the Orlistat dose can be omitted. Doses above the recommended daily dosage have not been found to provide any additional benefit.

    Orlistat is most effective when combined with other weight loss strategies such as sticking to a nutritionally balanced, minimized-calorie diet and regular exercises. You are advised to take the weight loss pill with a meal that contains about 30 percent calories from fat. The effects of the drug are seen as soon as 24-48 hours after taking a dose.

    Orlistat has been found to be effective in minimizing the absorption of certain fat-soluble vitamins and beta-carotene. As such, people who take the pill are advised to take it together with a multi-vitamin that contains fat-soluble vitamins to ensure sufficient nutrition. It’s recommended that the vitamin supplement be taken at least two hours before or after taking Orlistat.

    As for those patients receiving cyclosporine therapy, they are advised to administer cyclosporine at least 3 hours after taking Orlistat. For those receiving levothyroxine therapy, they are encouraged to administer levothyroxine therapy at least 4 hours after taking Orlistat. Those who take both Orlistat and levothyroxine should be observed carefully for changes in thyroid function.




    Orlistat powder:


    Weight Loss Orlistat Powder For the Treatment of Obesity and Hyperlipidemia CAS 96829-58-2


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    1. Professional team for package and shipment.Special way to ship 100grams to 100kg powders at one time to your country.


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    Contact Details
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